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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Financial

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

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Classification:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

,

cholesterol ester storage disease

,

,

failure to thrive

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

end stage liver disease

,

,

kidney transplantation

,

kidney diseases

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

,

complement activation

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

macular degeneration

,

geographic atrophy

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

myasthenia gravis

,

neuromyelitis optica

,

muscle weakness

,

delayed graft function

,

guillain-barre syndrome

,

left ventricular dysfunction

,

ventricular dysfunction

,

escherichia coli infections

,

shiga-toxigenic escherichia coli

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

hypophosphatasia

,

respiratory distress syndrome

,

,

acute lung injury

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

disease progression

healthy volunteers/patients

,

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

macular degeneration

,

geographic atrophy

,

,

paroxysmal hemoglobinuria

,

,

Mycophenolate sodium

immunosuppression therapy

,

healthy volunteers/patients

,

,

microscopic polyangiitis

,

systemic vasculitis

,

congenital abnormalities

,

urologic diseases

,

chronic kidney failure

,

systemic scleroderma

,

localized scleroderma

,

diffuse scleroderma

,

myelodysplastic syndromes

,

,

,

diabetes mellitus

,

,

,

interstitial lung diseases

,

,

iga glomerulonephritis

,

renal hypertension

,

bullous pemphigoid

,

,

lupus nephritis

,

,

systemic lupus erythematosus

,

type 1 diabetes mellitus

,

neuromyelitis optica

,

,

myasthenia gravis

,

muscle weakness

,

diabetic nephropathies

,

glomerulonephritis

,

multiple sclerosis

,

,

cardiovascular diseases

,

lung transplantation

,

,

pulmonary sarcoidosis

,

membranous glomerulonephritis

,

kidney transplantation

,

kidney diseases

,

liver transplantation

,

heart transplantation

,

renal insufficiency

,

polyomavirus infections

,

corneal transplantation

,

,

,

graft vs host disease

,

hematopoietic stem cell transplantation

Calcium carbonate

metabolic bone diseases

,

breast neoplasms

Antithrombin iii

neoplasm metastasis

,

,

gastroenteritis

,

rotavirus infections

,

intestinal neoplasms

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

,

,

colorectal neoplasms

,

myocardial infarction

,

coronary disease

,

,

follicular lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

large cell carcinoma

,

,

non-hodgkin lymphoma

,

non-small-cell lung carcinoma

,

,

papillomavirus infections

,

breast neoplasms

,

,

,

,

,

ovarian neoplasms

,

,

esophageal neoplasms

,

ovarian epithelial carcinoma

,

,

bacterial infections

,

,

uterine cervical neoplasms

,

vulvar neoplasms

,

condylomata acuminata

,

,

communicable diseases

,

head and neck neoplasms

,

squamous cell carcinoma

,

renal insufficiency

,

sleep initiation and maintenance disorders

,

vaginal neoplasms

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

,

triple negative breast neoplasms

,

,

squamous cell carcinoma of head and neck

,

squamous cell neoplasms

,

type 1 diabetes mellitus

,

chronic renal insufficiency

,

kidney diseases

,

,

general anesthesia

,

neuromuscular blockade

,

migraine disorders

,

,

,

,

,

clostridium infections

,

,

chronic hepatitis c

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

transitional cell carcinoma

,

fallopian tube neoplasms

,

,

bacterial pneumonia

,

,

alzheimer disease

,

,

adenocarcinoma in situ

,

alphapapillomavirus

,

herpes genitalis

,

pneumococcal infections

,

,

healthy volunteers/patients

,

human papillomavirus recombinant vaccine quadrivalent types 6 11 16 18

,

hereditary breast and ovarian cancer syndrome

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

rheumatoid arthritis

,

,

malignant mesothelioma

,

,

diabetes mellitus

,

type 2 diabetes mellitus

,

,

,

,

penile neoplasms

,

small cell lung carcinoma

muscular atrophy

,

spinal muscular atrophy

,

,

atherosclerosis

non-hodgkin lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

,

t-cell lymphoma

,

hodgkin disease

,

follicular lymphoma

,

b-cell lymphoma

,

lymphoid leukemia

healthy volunteers/patients

,

pancreatic neoplasms

,

myelodysplastic-myeloproliferative diseases

,

leukemia myeloid chronic atypical bcr-abl negative

,

,

,

cutaneous malignant melanoma

,

,

medication adherence

,

second primary neoplasms

,

ovarian epithelial carcinoma

,

,

,

multiple myeloma

,

follicular lymphoma

,

mantle-cell lymphoma

,

biphenotypic leukemia acute

,

t-cell lymphoma

,

neoplasm metastasis

,

myelomonocytic leukemia acute

,

ovarian neoplasms

,

large b-cell lymphoma diffuse

,

eyelid neoplasms

,

t-cell lymphoma peripheral

,

myeloid leukemia chronic-phase

,

,

fallopian tube neoplasms

,

medulloblastoma

,

triple negative breast neoplasms

,

,

b-cell lymphoma marginal zone

,

burkitt lymphoma

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

castration-resistant prostatic neoplasms

,

,

myeloid leukemia accelerated phase

,

refractory anemia with excess of blasts

,

,

primitive neuroectodermal tumors

,

neuroectodermal tumors

,

renal cell carcinoma

,

,

brain neoplasms

,

extranodal nk-t-cell lymphoma

,

waldenstrom macroglobulinemia

,

large-cell lymphoma anaplastic

,

large-cell lymphoma immunoblastic

,

,

diabetes mellitus

,

,

hepatocellular carcinoma

,

liver neoplasms

,

residual neoplasm

,

,

islet cell adenoma

,

,

nervous system neoplasms

,

primitive neuroectodermal tumors peripheral

,

,

,

oligodendroglioma

,

myeloid sarcoma

,

,

ganglioneuroblastoma

,

ovarian hyperstimulation syndrome

,

,

sezary syndrome

,

immunoblastic lymphadenopathy

,

mycosis fungoides

,

adult t-cell leukemia-lymphoma

,

intraocular lymphoma

,

t-cell lymphoma cutaneous

,

plasmablastic lymphoma

,

t-cell leukemia

,

lymphomatoid granulomatosis

,

sickle cell anemia

,

,

systemic lupus erythematosus

,

biliary tract neoplasms

,

immunologic deficiency syndromes

,

hematopoietic stem cell transplantation

,

erythroblastic leukemia acute

,

pathologic complete response

,

head and neck neoplasms

,

wounds and injuries

,

,

,

thyroid neoplasms

,

papillary thyroid cancer

,

thyroid diseases

,

follicular adenocarcinoma

,

papillary carcinoma

,

type 1 diabetes mellitus

,

urinary retention

,

,

urinary tract infections

,

pelvic organ prolapse

,

,

male breast neoplasms

,

pulmonary alveolar proteinosis

,

hematologic diseases

,

clostridium infections

,

bone marrow transplantation

,

,

basal cell carcinoma

,

merkel cell carcinoma

,

basal cell neoplasms

,

hypersensitivity

,

graft vs host disease

,

prolymphocytic leukemia

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

,

,

,

non-hodgkin lymphoma

,

myeloproliferative disorders

,

philadelphia chromosome

,

hematologic neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

non-small-cell lung carcinoma

,

geographic atrophy

,

,

breast neoplasms

,

plasma cell neoplasms

,

b-cell lymphoma

,

prostatic neoplasms

,

b-cell chronic lymphocytic leukemia

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

rhabdomyosarcoma

,

primary myelofibrosis

,

central nervous system neoplasms

,

,

mucocutaneous lymph node syndrome

,

,

,

,

,

macular degeneration

,

,

spinal cord neoplasms

,

,

neuroendocrine tumors

,

colorectal neoplasms

,

induction chemotherapy

,

venous thromboembolism

,

thromboembolism

,

,

,

,

ischemic stroke

,

,

,

brain stem neoplasms

,

muscle spasticity

,

,

invasive hydatidiform mole

,

,

nephrotic syndrome

,

,

pulmonary embolism

,

,

autonomic nervous system diseases

,

,

primary dysautonomias

,

familial dysautonomia

,

hydatidiform mole

,

gestational trophoblastic disease

,

choriocarcinoma

,

trophoblastic neoplasms

,

juvenile arthritis

,

kidney neoplasms

,

,

,

myeloid leukemia acute

,

myeloid leukemia

,

myelodysplastic syndromes

,

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

,

,

rheumatoid arthritis

,

,

,

aplastic anemia

,

,

inflammatory bowel diseases

,

ulcerative colitis

,

,

,

kidney diseases

,

,

iga glomerulonephritis

,

child mortality

,

growth and development

,

critical illness

,

premature birth

,

intestinal diseases

,

lupus nephritis

,

,

kidney transplantation

,

,

,

,

,

acute coronary syndrome

,

coronary artery disease

,

percutaneous coronary intervention

,

gastrointestinal diseases

,

cardiovascular diseases

,

gastrointestinal stromal tumors

,

,

esophageal neoplasms

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

,

thrombocytopenia

,

germ cell and embryonal neoplasms

,

,

retinal neoplasms

,

phenylketonurias

,

heart disease risk factors

,

stomatognathic diseases

,

endocrine system diseases

,

autoimmune diseases

,

cognitive dysfunction

,

neurocognitive disorders

,

major depressive disorder

,

depressive disorder

,

,

type 2 diabetes mellitus

,

chronic periodontitis

,

,

,

drug-related side effects and adverse reactions

,

digestive system diseases

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

Choline alfoscerate

alzheimer disease

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2

3

4

5

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