Alexion Pharmaceuticals - PharmaKB

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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Marketed Drugs

Clinical Trials

Financial

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Company Revenue

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Annual

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Projections

*Quarterly sales USD (in millions)

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

psychology rejection

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

anti-glomerular basement membrane disease

,

myasthenia gravis

,

kidney transplantation

,

muscle weakness

,

vascular diseases

,

thrombotic microangiopathies

,

guillain-barre syndrome

,

delayed graft function

,

,

escherichia coli infections

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

,

paroxysmal hemoglobinuria

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

,

neuromyelitis optica

,

,

coronavirus infections

,

respiratory distress syndrome

,

,

acute lung injury

,

hypophosphatasia

,

severe acute respiratory syndrome

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

healthy volunteers/patients

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

geographic atrophy

,

paroxysmal hemoglobinuria

,

,

,

Mycophenolate sodium

immunosuppression therapy

,

healthy volunteers/patients

,

microscopic polyangiitis

,

congenital abnormalities

,

chronic kidney failure

,

systemic scleroderma

,

myelodysplastic syndromes

,

,

,

,

,

interstitial lung diseases

,

localized scleroderma

,

diffuse scleroderma

,

,

iga glomerulonephritis

,

renal hypertension

,

diabetes mellitus

,

bullous pemphigoid

,

,

lupus nephritis

,

,

systemic lupus erythematosus

,

type 1 diabetes mellitus

,

neuromyelitis optica

,

,

myasthenia gravis

,

diabetic nephropathies

,

multiple sclerosis

,

cardiovascular diseases

,

lung transplantation

,

,

pulmonary sarcoidosis

,

membranous glomerulonephritis

,

kidney transplantation

,

liver transplantation

,

heart transplantation

,

kidney diseases

,

renal insufficiency

,

polyomavirus infections

,

corneal transplantation

,

,

,

graft vs host disease

,

hematopoietic stem cell transplantation

,

non-alcoholic fatty liver disease

,

,

psoriatic arthritis

,

,

alzheimer disease

,

,

hepatic insufficiency

,

,

insulin resistance

,

,

acute coronary syndrome

,

cardiac catheterization

,

heart valve prosthesis

,

venous thrombosis

,

systolic murmurs

,

polycystic kidney diseases

,

chronic renal insufficiency

,

chronic kidney failure

,

secondary prevention

,

neoplasm metastasis

,

replacement arthroplasty knee

,

,

,

disease progression

,

,

percutaneous coronary intervention

,

replacement arthroplasty hip

,

intracranial sinus thrombosis

,

healthy volunteers/patients

,

,

atrial fibrillation

,

thromboembolism

,

venous thromboembolism

,

essential hypertension

,

renal insufficiency

,

kidney diseases

,

,

,

cardiovascular diseases

,

isolated systolic hypertension

,

coronary artery disease

,

myocardial ischemia

,

diabetic nephropathies

,

coronary disease

,

arteriosclerosis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

metabolic syndrome

,

heart valve diseases

,

replacement arthroplasty

,

cognitive dysfunction

,

,

,

,

,

cerebral infarction

,

myocardial infarction

,

,

,

,

cognition disorders

,

,

,

,

transient ischemic attack

,

,

liver cirrhosis

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

insulin resistance

,

kidney diseases

,

chronic hepatitis d

,

,

patient acceptance of health care

,

,

relapsing-remitting multiple sclerosis

,

drug-related side effects and adverse reactions

,

progressive multifocal leukoencephalopathy

,

hepatitis b virus

,

,

chronic kidney failure

,

treatment adherence and compliance

,

,

hepatocellular carcinoma

,

liver neoplasms

,

,

,

,

,

acquired immunodeficiency syndrome

,

chronic hepatitis b

,

,

,

chronic hepatitis

,

,

,

,

substance-related disorders

,

medication adherence

,

,

,

communicable diseases

,

healthy volunteers/patients

,

,

chronic renal insufficiency

,

,

,

persistent infection

,

cognitive dysfunction

,

chronic hepatitis c

,

patient compliance

,

,

,

,

kidney transplantation

,

non-hodgkin lymphoma

,

burkitt lymphoma

,

,

,

sleep wake disorders

,

anxiety disorders

,

opioid-related disorders

,

metabolic bone diseases

,

morphine dependence

,

renal insufficiency

,

,

,

recreational drug use

,

,

hiv seropositivity

,

,

biliary liver cirrhosis

,

,

cardiovascular diseases

,

metabolic diseases

,

retinal diseases

,

metabolic syndrome

,

drug interactions

Choline alfoscerate

alzheimer disease

,

hypercholesterolemia

,

hyperlipidemias

,

metabolic diseases

,

congenital abnormalities

,

,

inborn genetic diseases

,

metabolic syndrome

,

metabolic brain diseases

,

newborn infant diseases

,

lipid metabolism disorders

,

inborn errors metabolism

,

hyperlipoproteinemias

,

inborn errors lipid metabolism

,

hypolipoproteinemias

,

hypobetalipoproteinemias

,

lymphoid leukemia

,

squamous cell carcinoma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

interdigitating dendritic cell sarcoma

,

squamous cell neoplasms

,

adenosquamous carcinoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

philadelphia chromosome

,

myelodysplastic syndromes

,

graft vs host disease

,

gata2 deficiency

,

neoplasm metastasis

,

small cell carcinoma

,

neuroendocrine carcinoma

,

squamous cell carcinoma of head and neck

,

mouth neoplasms

,

gastrointestinal neoplasms

,

adenoviridae infections

,

,

,

,

,

,

pancreatic neoplasms

,

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

ovarian neoplasms

,

non-small-cell lung carcinoma

,

,

serous cystadenocarcinoma

,

b-cell lymphoma

,

colorectal neoplasms

,

myeloid leukemia acute

,

prostatic neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hematologic neoplasms

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

cholangiocarcinoma

,

malignant mesothelioma

,

,

,

pancreatic ductal carcinoma

,

ovarian epithelial carcinoma

,

,

triple negative breast neoplasms

,

myeloid leukemia

,

head and neck neoplasms

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

breast neoplasms

,

multiple myeloma

,

plasma cell neoplasms

1

2

3

4

5

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