Alexion Pharmaceuticals - PharmaKB

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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Financial

Marketed Drugs

Clinical Trials

Financial

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*Currency in USD

Company Revenue

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Annual

Annual

Projections

*Quarterly sales USD (in millions)

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

mucopolysaccharidosis iv

,

mucopolysaccharidosis vi

,

glycogen storage disease type ii

,

sudden infant death

,

mucopolysaccharidosis vii

,

gaucher disease

,

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

,

vascular diseases

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

psychology rejection

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

anti-glomerular basement membrane disease

,

myasthenia gravis

,

kidney transplantation

,

thrombotic microangiopathies

,

muscle weakness

,

guillain-barre syndrome

,

delayed graft function

,

,

escherichia coli infections

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

,

paroxysmal hemoglobinuria

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

neuromyelitis optica

,

,

,

coronavirus infections

,

respiratory distress syndrome

,

,

acute lung injury

,

multiple sclerosis

,

magnetic resonance imaging

,

neuroinflammatory diseases

,

hypophosphatasia

,

severe acute respiratory syndrome

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

,

hematopoietic stem cell transplantation

healthy volunteers/patients

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

geographic atrophy

,

paroxysmal hemoglobinuria

,

,

,

Mycophenolate sodium

healthy volunteers/patients

healthy volunteers/patients

,

type 2 diabetes mellitus

,

,

,

,

non-small-cell lung carcinoma

,

,

respiratory syncytial virus infections

,

brain neoplasms

,

central nervous system neoplasms

,

,

glucose metabolism disorders

,

metabolic diseases

,

alzheimer disease

,

huntington disease

,

thyroid neoplasms

,

,

sickle cell anemia

,

atopic dermatitis

,

,

colorectal neoplasms

,

anxiety disorders

,

prostatic neoplasms

,

breast neoplasms

,

,

adenocarcinoma of lung

,

generalized anxiety disorder

,

reflex epilepsy

,

bipolar disorder

,

diabetes mellitus

,

,

status epilepticus

,

critical illness

,

,

psychomotor agitation

,

post-traumatic stress disorders

,

executive function

,

,

partial epilepsies

,

generalized epilepsy

,

complex partial epilepsy

,

,

insulin resistance

,

metabolic syndrome

,

,

major depressive disorder

,

depressive disorder

,

psychotic disorders

,

gastrointestinal endoscopy

,

hyperlipidemias

,

,

non-alcoholic fatty liver disease

,

,

psoriatic arthritis

,

,

alzheimer disease

,

,

hepatic insufficiency

,

,

insulin resistance

,

,

acute coronary syndrome

,

cardiac catheterization

,

heart valve prosthesis

,

venous thrombosis

,

systolic murmurs

,

polycystic kidney diseases

,

chronic renal insufficiency

,

chronic kidney failure

,

secondary prevention

,

neoplasm metastasis

,

replacement arthroplasty knee

,

,

,

disease progression

,

,

percutaneous coronary intervention

,

replacement arthroplasty hip

,

intracranial sinus thrombosis

,

healthy volunteers/patients

,

,

atrial fibrillation

,

thromboembolism

,

venous thromboembolism

,

essential hypertension

,

renal insufficiency

,

kidney diseases

,

,

,

cardiovascular diseases

,

isolated systolic hypertension

,

coronary artery disease

,

myocardial ischemia

,

diabetic nephropathies

,

coronary disease

,

arteriosclerosis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

metabolic syndrome

,

heart valve diseases

,

replacement arthroplasty

,

cognitive dysfunction

,

,

,

,

,

cerebral infarction

,

myocardial infarction

,

,

,

,

cognition disorders

,

,

,

,

transient ischemic attack

,

,

liver cirrhosis

b-cell chronic lymphocytic leukemia

,

,

t-cell lymphoma

,

hodgkin disease

,

follicular lymphoma

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

bronchiolitis obliterans syndrome

,

non-hodgkin lymphoma

myocardial infarction

,

,

inferior wall myocardial infarction

,

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

Choline alfoscerate

general anesthesia

,

neuromuscular blockade

neuroendocrine carcinoma

,

neoplasm metastasis

,

neuroendocrine tumors

,

,

carcinoid tumor

,

,

serotonin syndrome

,

nontuberculous mycobacterium infections

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

1

2

3

4

5

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