Alexion Pharmaceuticals - PharmaKB

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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Marketed Drugs

Clinical Trials

Financial

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Company Revenue

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Annual

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*Quarterly sales USD (in millions)

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

mucopolysaccharidosis iv

,

glycogen storage disease type ii

,

lysosomal storage diseases

,

gaucher disease

,

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

neuromyelitis optica

,

myasthenia gravis

,

kidney transplantation

,

muscle weakness

,

vascular diseases

,

thrombotic microangiopathies

,

guillain-barre syndrome

,

delayed graft function

,

escherichia coli infections

,

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

,

,

coronavirus infections

,

hypophosphatasia

,

respiratory distress syndrome

,

,

acute lung injury

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

healthy volunteers/patients

,

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

macular degeneration

,

geographic atrophy

,

,

paroxysmal hemoglobinuria

,

,

Mycophenolate sodium

hyperlipoproteinemia type i

Calcium carbonate

metabolic bone diseases

,

breast neoplasms

cardiovascular diseases

non-hodgkin lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

hodgkin disease

,

b-cell lymphoma

,

lymphoid leukemia

,

,

,

t-cell lymphoma

,

follicular lymphoma

,

large-cell lymphoma anaplastic

,

t-cell lymphoma peripheral

healthy volunteers/patients

,

healthy volunteers/patients

,

b-cell chronic lymphocytic leukemia

,

,

colonic neoplasms

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

knee osteoarthritis

,

,

,

,

rectal neoplasms

,

lymphoid leukemia

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

,

glycogen storage disease

,

,

deficiency diseases

,

essential thrombocythemia

,

polycythemia vera

,

,

,

,

,

falciparum malaria

,

hereditary nephritis

,

,

,

,

viral hemorrhagic fevers

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

langerhans-cell histiocytosis

,

hypersensitivity

,

peanut hypersensitivity

,

allergic rhinitis

,

,

esophageal neoplasms

,

stomach neoplasms

,

,

myeloid leukemia acute

,

myeloid leukemia

,

colorectal neoplasms

,

prostatic neoplasms

,

venous thromboembolism

,

thromboembolism

,

primary myelofibrosis

,

hypercholesterolemia

,

gaucher disease

,

head and neck neoplasms

,

rheumatoid arthritis

,

,

hematologic neoplasms

,

,

,

thyroid neoplasms

,

thyroid diseases

,

multiple myeloma

,

plasma cell neoplasms

,

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

,

tay-sachs disease

,

sandhoff disease

,

,

,

,

haemophilus influenzae type b

,

,

,

neurotoxicity syndromes

,

brugada syndrome

,

chronic kidney failure

,

renal insufficiency

,

type 2 diabetes mellitus

,

diabetes mellitus

,

type 1 diabetes mellitus

,

glycogen storage disease type ii

,

,

atopic dermatitis

,

,

,

,

human influenza

,

,

,

,

,

atrial fibrillation

,

,

,

meningococcal infections

,

,

sedentary behavior

,

,

wounds and injuries

,

heart transplantation

,

reperfusion injury

,

,

,

clostridium infections

,

,

chronic renal insufficiency

,

kidney diseases

,

cardiovascular diseases

,

,

,

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

Choline alfoscerate

healthy volunteers/patients

,

cardiovascular diseases

,

,

,

child development

,

,

male infertility

,

,

esophageal neoplasms

,

,

non-hodgkin lymphoma

,

,

hodgkin disease

,

large b-cell lymphoma diffuse

,

food diet and nutrition

,

lymphangioleiomyomatosis

,

,

,

pharmacokinetics

,

,

hepatocellular carcinoma

,

liver neoplasms

,

fetal alcohol spectrum disorders

,

breast neoplasms

,

cystic fibrosis

,

,

,

,

triple negative breast neoplasms

,

substance-related disorders

,

cognition disorders

,

neurodevelopmental disorders

,

marijuana abuse

,

heart valve diseases

,

,

,

myeloid leukemia acute

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

myeloid leukemia

,

erythroblastic leukemia acute

,

hypersensitivity

,

,

,

reperfusion injury

,

myocardial reperfusion injury

,

,

,

exocrine pancreatic insufficiency

,

,

,

cerebellar ataxia

,

,

prostatic neoplasms

,

,

,

hyperparathyroidism

,

hypertriglyceridemia

,

,

non-alcoholic fatty liver disease

,

,

prader-willi syndrome

,

hepatolenticular degeneration

,

coronary artery disease

,

premature birth

,

,

,

primary hyperparathyroidism

,

ischemic stroke

,

open-angle glaucoma

,

parathyroid neoplasms

,

coronary disease

,

myocardial ischemia

,

metabolic syndrome

,

,

,

diabetic neuropathies

,

multiple myeloma

,

plasma cell neoplasms

,

,

,

brain hypoxia-ischemia

,

severe acute malnutrition

,

castration-resistant prostatic neoplasms

,

parathyroid diseases

,

rapid sequence induction and intubation

,

hyperhomocysteinemia

,

liver cirrhosis

,

atherosclerotic plaque

,

,

,

iron-deficiency anemia

,

iron deficiencies

,

neuroprotection

,

cognitive dysfunction

,

,

alzheimer disease

,

,

,

,

,

,

cerebral infarction

,

,

diabetes mellitus

,

,

,

wounds and injuries

,

traumatic brain injuries

,

,

optic nerve diseases

,

,

,

,

atherosclerosis

,

bipolar disorder

,

peripheral nervous system diseases

,

ischemic optic neuropathy

,

,

myocardial infarction

,

cocaine-related disorders

,

,

type 2 diabetes mellitus

,

alcohol drinking

,

microvascular angina

,

chemical and drug induced liver injury

,

asperger syndrome

,

,

autistic disorder

,

psychotic disorders

,

,

,

,

alcoholic hepatitis

,

postoperative pain

,

neural conduction

,

carotid artery diseases

,

respiratory aspiration

,

,

,

,

heart disease risk factors

,

brain neoplasms

,

,

depressive disorder

,

neoplasm metastasis

,

,

,

,

thyroid neoplasms

,

neuroendocrine carcinoma

,

thyroid diseases

,

major depressive disorder

,

choline deficiency

,

anxiety disorders

,

,

,

prostatic hyperplasia

,

neuroendocrine tumors

,

,

,

,

body weight changes

,

,

,

non-small-cell lung carcinoma

,

infant nutrition disorders

,

alcoholic liver diseases

,

,

papillary thyroid cancer

,

coronary stenosis

,

,

bone marrow diseases

,

,

erdheim-chester disease

,

,

langerhans-cell histiocytosis

,

tourette syndrome

,

myasthenia gravis

,

muscle weakness

,

amphetamine-related disorders

,

,

,

liver transplantation

,

,

gestational diabetes

,

,

,

neurodegenerative diseases

,

,

,

carotid stenosis

,

irritable bowel syndrome

,

positron-emission tomography

,

total parenteral nutrition

,

endometrial neoplasms

,

uterine cervical neoplasms

,

,

lymphatic metastasis

,

muscle strength

,

,

uveal neoplasms

,

urologic neoplasms

,

amyotrophic lateral sclerosis

,

muscle spasticity

,

motor neuron disease

,

hereditary spastic paraplegia

,

,

,

intestinal failure

,

postpartum depression

,

,

hypercholesterolemia

,

,

,

communicable diseases

,

,

essential hypertension

,

,

,

,

neurotoxicity syndromes

,

peripheral nerve injuries

,

nerve degeneration

,

organophosphate poisoning

,

neuroinflammatory diseases

,

obstetrical anesthesia

,

emotional regulation

,

executive function

,

cold temperature

,

gastrointestinal diseases

,

digestive system diseases

,

,

,

,

exercise tolerance

,

therapeutic chemoembolization

,

head and neck neoplasms

,

gastrointestinal neoplasms

,

urogenital neoplasms

,

,

intestinal neoplasms

,

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