Alexion Pharmaceuticals - PharmaKB

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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Financial

Marketed Drugs

Clinical Trials

Financial

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*Currency in USD

Company Revenue

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Annual

Annual

Projections

*Quarterly sales USD (in millions)

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

,

vascular diseases

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

psychology rejection

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

anti-glomerular basement membrane disease

,

,

,

hemolytic-uremic syndrome

,

,

myasthenia gravis

,

kidney transplantation

,

thrombotic microangiopathies

,

muscle weakness

,

guillain-barre syndrome

,

delayed graft function

,

,

escherichia coli infections

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

,

paroxysmal hemoglobinuria

,

,

atypical hemolytic uremic syndrome

,

neuromyelitis optica

,

,

coronavirus infections

,

respiratory distress syndrome

,

,

acute lung injury

,

multiple sclerosis

,

magnetic resonance imaging

,

neuroinflammatory diseases

,

hypophosphatasia

,

severe acute respiratory syndrome

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

,

hematopoietic stem cell transplantation

healthy volunteers/patients

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

geographic atrophy

,

paroxysmal hemoglobinuria

,

,

,

Mycophenolate sodium

immunosuppression therapy

,

healthy volunteers/patients

,

microscopic polyangiitis

,

congenital abnormalities

,

chronic kidney failure

,

systemic scleroderma

,

myelodysplastic syndromes

,

,

,

,

,

interstitial lung diseases

,

localized scleroderma

,

diffuse scleroderma

,

,

iga glomerulonephritis

,

renal hypertension

,

diabetes mellitus

,

bullous pemphigoid

,

,

lupus nephritis

,

,

systemic lupus erythematosus

,

type 1 diabetes mellitus

,

neuromyelitis optica

,

,

myasthenia gravis

,

diabetic nephropathies

,

multiple sclerosis

,

cardiovascular diseases

,

lung transplantation

,

,

pulmonary sarcoidosis

,

membranous glomerulonephritis

,

kidney transplantation

,

liver transplantation

,

heart transplantation

,

kidney diseases

,

renal insufficiency

,

polyomavirus infections

,

corneal transplantation

,

,

,

graft vs host disease

,

hematopoietic stem cell transplantation

rheumatoid arthritis

,

,

healthy volunteers/patients

,

alzheimer disease

,

,

,

,

,

graft rejection

,

diabetes mellitus

,

insulin resistance

,

metabolic syndrome

,

,

non-alcoholic fatty liver disease

,

,

psoriatic arthritis

,

,

alzheimer disease

,

,

hepatic insufficiency

,

,

insulin resistance

,

,

acute coronary syndrome

,

cardiac catheterization

,

heart valve prosthesis

,

venous thrombosis

,

systolic murmurs

,

polycystic kidney diseases

,

chronic renal insufficiency

,

chronic kidney failure

,

secondary prevention

,

neoplasm metastasis

,

replacement arthroplasty knee

,

,

,

disease progression

,

,

percutaneous coronary intervention

,

replacement arthroplasty hip

,

intracranial sinus thrombosis

,

healthy volunteers/patients

,

,

atrial fibrillation

,

thromboembolism

,

venous thromboembolism

,

essential hypertension

,

renal insufficiency

,

kidney diseases

,

,

,

cardiovascular diseases

,

isolated systolic hypertension

,

coronary artery disease

,

myocardial ischemia

,

diabetic nephropathies

,

coronary disease

,

arteriosclerosis

,

type 2 diabetes mellitus

,

diabetes mellitus

,

metabolic syndrome

,

heart valve diseases

,

replacement arthroplasty

,

cognitive dysfunction

,

,

,

,

,

cerebral infarction

,

myocardial infarction

,

,

,

,

cognition disorders

,

,

,

,

transient ischemic attack

,

,

liver cirrhosis

b-cell chronic lymphocytic leukemia

,

,

hodgkin disease

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

bronchiolitis obliterans syndrome

,

,

t-cell lymphoma

,

follicular lymphoma

,

,

large-cell lymphoma anaplastic

,

t-cell lymphoma peripheral

,

non-hodgkin lymphoma

myocardial infarction

,

,

inferior wall myocardial infarction

,

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

healthy volunteers/patients

,

,

aids-related lymphoma

,

progressive multifocal leukoencephalopathy

,

chronic hepatitis d

,

,

,

,

,

,

,

chronic hepatitis b

,

acquired immunodeficiency syndrome

,

chronic hepatitis

,

Choline alfoscerate

,

,

coronary disease

,

breast neoplasms

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

plasma cell neoplasms

,

hodgkin disease

,

,

breast neoplasms

,

,

mucinous adenocarcinoma

,

ductal carcinoma breast

,

inflammatory breast neoplasms

,

non-hodgkin lymphoma

,

mantle-cell lymphoma

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

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2

3

4

5

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